Iidipeptides

I-L-α-dipeptides (i-dipeptides) ayizange ifundwe phantse njengoko ininzi ineeprotheni kunye ne-amino acids.Uphando oluphambili lwenziwe kwi-L-aspartyl-L-phenylalanine methylester (aspartame) kunye ne-Ala-Gln (i-Lalanyl-L-glutamine) kuba zisetyenziswa kwiimveliso zorhwebo ezidumileyo.Ukongeza kule nyaniso, esinye isizathu sokuba ezininzi iipeptides zingafundwanga ngokucokisekileyo kukuba imveliso yeedipeptide ayinazo iinkqubo zokuvelisa ezisebenzayo, nangona iindlela ezininzi zeekhemikhali kunye neekhemoenzymatic ziye zaxelwa.

Carnosine - umzekelo dipeptide
Ukuza kuthi ga mva nje, kuphuhliswe iindlela ezintsha zedipeptide synthesis apho iidipeptides ziveliswa ngeenkqubo zokuvundisa.Ezinye iipeptide zinamandla ohlukileyo okuphila ngokwasemzimbeni, okubavumela ukuba bakhawulezise usetyenziso lweedipeptide kwiinkalo ezahlukeneyo zophando lwezenzululwazi.I-L-α-dipeptides iqulethwe yeyona peptide bond engantsonkothanga yee-amino acids ezimbini, kodwa azifumaneki ngokulula ngenxa yokungabizi kakhulu kweenkqubo zokwenziwa kwemveliso.I-Dipeptides, nangona kunjalo, inemisebenzi enomdla kakhulu, kwaye ulwazi lwezenzululwazi olujikelezayo luyanda.Oku kushiya abaphandi abaninzi ngentlawulo yokuphuhlisa iinkqubo ezisebenzayo kunye neendleko zokwenziwa kweedipeptide.Xa lo mmandla uphononongwa ngokupheleleyo, kucingelwa ukuba sinokufunda ngakumbi malunga nokuba zixabiseke kangakanani iipeptides.

Iidipeptides zinemisebenzi emibini esisiseko, eyile:
1. I-derivative ye-amino acids
2. Idipeptide ngokwayo

Njengenye yee-amino acids, ii-dipeptides, kunye nee-amino acids zazo zineempawu ezahlukeneyo ze-physiochemical, kodwa zihlala zibelana ngeziphumo ezifanayo zomzimba.Oku kungenxa yokuba i-dipeptides ithotywa kwi-amino acids eyahlukileyo kwizinto eziphilayo, ezineempawu ezahlukeneyo ze-physicochemical.Ngokomzekelo, i-L-glutamine (Gln) i-heat-labile, ngelixa i-Ala-Gin (L-alanyl-L-glutamine) inyamezela ukushisa.

Ukwenziwa kweekhemikhali zeedipeptides kwenzeka ngolu hlobo lulandelayo:
1. Onke amaqela e-dipeptide asebenzayo akhuselwe (ngaphandle kwalawo abandakanyekayo ekudaleni i-peptide bond yee-amino acids).
2. I-amino acid ekhuselweyo yeqela le-carboxyl yasimahla iyasebenza.
3. I-amino acid esebenzayo isabela kunye nenye ekhuselweyo i-amino acid.
4. Amaqela akhuselayo aqulethwe kwidipeptide ayasuswa.